| Pos. | Title | Artist | Label |
| 1 | BLEEDING LOVE | LEONA LEWIS | SVCO/J/RMG |
| 2 | FOREVER | CHRIS BROWN | Jive/Zomba |
| 3 | LOW | FLO RIDA FEATURING T-PAIN | Poe Boy/Atlantic |
| 4 | DISTURBIA | RIHANNA | Def Jam/IDJMG |
| 5 | LEAVIN' | JESSE McCARTNEY | Hollywood |
| 6 | LOVE SONG | SARA BAREILLES | Epic |
| 7 | NO AIR | JORDIN SPARKS DUET WITH CHRIS BROWN | 19/Jive/Zomba |
| 8 | TAKE A BOW | RIHANNA | Def Jam/IDJMG |
| 9 | WITH YOU | CHRIS BROWN | Jive/Zomba |
| 10 | LOVE IN THIS CLUB | USHER FEATURING YOUNG JEEZY | Jive/Zomba |
| 11 | POCKETFUL OF SUNSHINE | NATASHA BEDINGFIELD | Phonogenic/Epic |
| 12 | LOLLIPOP | LIL WAYNE FEATURING STATIC MAJOR | Cash Money/Universal Motown |
| 13 | SO WHAT | PINK | LaFace/Zomba |
| 14 | I KISSED A GIRL | KATY PERRY | Capitol |
| 15 | SEXY CAN I | RAY J & YUNG BERG | Knockout/Deja 34/Epic |
| 16 | APOLOGIZE | TIMBALAND FEATURING ONE REPUBLIC | Mosley/Blackground/Interscope |
| 17 | CLOSER | NE-YO | Def Jam/IDJMG |
| 18 | DON'T STOP THE MUSIC | RIHANNA | Def Jam/IDJMG |
| 19 | SEE YOU AGAIN | MILEY CYRUS | Hollywood |
| 20 | HOT N COLD | KATY PERRY | Capitol |
| 21 | SHAHE IT | METRO STATION | Columbia |
| 22 | NO ONE | ALICIA KEYS | J/RMG |
| 23 | WHATEVER YOU LIKE | T.I. | Grand Hustle/Atlantic |
| 24 | VIVA LA VIDA | COLDPLAY | Capitol |
| 25 | STOP AND STARE | ONEREPUBLIC | Mosley/Blackground/Interscope |
| 26 | SORRY | BUCKCHERRY | Eleven Seven/Atlantic/Lava |
| 27 | DANGEROUS | KARDINAL OFFISHALL FEATURING AKON | Konlive/Geffen/Interscope |
| 28 | BETTER IN TIME | LEONA LEWIS | SVCO/J/RMG |
| 29 | 4 MINUTES | MADONNA FEATURING JUSTIN TIMBERLAKE | Warner Bros. |
| 30 | DAMAGED | DANITY KANE | Bad Boy/Atlantic |
| 31 | I'M YOURS | JASON MRAZ | Atlantic/RRP |
| 32 | TAKE YOU THERE | SEAN KINGSTON | Beluga Heights/Epic |
| 33 | LET IT ROCK | KEVIN RUDOLF FEAT. LIL WAYNE | Cash Money/Universal Republic |
| 34 | TOUCH MY BODY | MARIAH CAREY | Island/IDJMG |
| 35 | FALL FOR YOU | SECONDHAND SERENADE | Glassnote/ILG/Atlantic |
| 36 | ONE STEP AT A TIME | JORDIN SPARKS | 19/Jive/Zomba |
| 37 | CLUMSY | FERGIE | A&M/Interscope |
| 38 | WHEN I GROW UP | PUSSYCAT DOLLS | Interscope |
| 39 | LIVE YOUR LIFE | T.I. FEATURING RIHANNA | Def Jam/Grand Hustle/IDJMG/Atlantic |
| 40 | WOMANIZER | BRITNEY SPEARS | Jive/Zomba |
| 41 | TATTOO | JORDIN SPARKS | Jive/Zomba |
| 42 | TEARDROPS ON MY GUITAR | TAYLOR SWIFT | Big Machine/Universal Republic |
| 43 | REALIZE | COLBIE CAILLAT | Universal Republic |
| 44 | PAPER PLANES | M.I.A. | XL/Interscope |
| 45 | IT'S NOT MY TIME | 3 DOORS DOWN | Universal Republic |
| 46 | WHAT YOU GOT | COLBY O'DONIS FEATURING AKON | Konlive/Geffen/Interscope |
| 47 | PARALYZER | FINGER ELEVEN | Wind-Up |
| 48 | CRUSH | DAVID ARCHULETA | 19/Jive/Zomba |
| 49 | ALL SUMMER LONG | KID ROCK | Top Dog/Atlantic |
| 50 | MISS INDEPENDENT | NE-YO | Def Jam/IDJMG |
| 51 | AMERICAN BOY | ESTELLE FEATURING KANYE WEST | Home School/Atlantic |
| 52 | KISS KISS | CHRIS BROWN FEATURING T-PAIN | Jive/Zomba |
| 53 | IF I WERE A BOY | BEYONCE | Columbia |
| 54 | SHADOW OF THE DAY | LINKIN PARK | Warner Bros. |
| 55 | ADDICTED | SAVING ABEL | Skiddco/Virgin/Capitol |
| 56 | IN THE AYER | FLO RIDA FEATURING WILL.I.AM | Poe Boy/Atlantic |
| 57 | IN LOVE WITH A GIRL | GAVIN DeGRAW | J/RMG |
| 58 | SWEETEST GIRL(DOLLAR BILL) | WYCLEF JEAN FEATURING AKON, LIL WAYNE & NIIA | Columbia |
| 59 | LOVE LOCKDOWN | KANYE WEST | Roc-A-Fella/Def Jam/IDJMG |
| 60 | BURNIN' UP | JONAS BROTHERS | Hollywood |
| 61 | RIGHT NOW(NA NA NA) | AKON | SRC/Universal Motown |
| 62 | NEVER TOO LATE | THREE DAYS GRACE | Jive/Zomba |
| 63 | GOTTA BE SOMEBODY | NICKELBACK | Roadrunner/IDJMG |
| 64 | BUBBLY | COLBIE CAILLAT | Universal Republic |
| 65 | SUPERSTAR | LUPE FIASCO | 1st&15th/Atlantic |
| 66 | KEEPS GETTIN' BETTER | CHRISTINA AGUILERA | RCA/RMG |
| 67 | BUST IT BABY(PART 2) | PLIES FEATURING NE-YO | Big Gates/Slip-n-Slide/Atlantic |
| 68 | HATE THAT I LOVE YOU | RIHANNA FEATURING NE-YO | Def Jam/IDJMG |
| 69 | LOVE STORY | TAYLOR SWIFT | Big Machine |
| 70 | CAN'T BELIEVE IT | T-PAIN FEATURING LIL WAYNE | Nappy Boy/Konvict/Jive/Zomba |
| 71 | OVER YOU | DAUGHTRY | RCA/RMG |
| 72 | LOVE LIKE THIS | NATASHA BEDINGFIELD FEATURING SEAN KINGSTON | Phonogenic/Epic |
| 73 | ALL AROUND ME | FLYLEAF | A&M/Octone/Interscope |
| 74 | JUST DANCE | LADY GAGA FEATURING COLBY O'DONIS | Stemline/KonLive/Cherrytree/Interscope |
| 75 | SENSUAL DESUCTION | SNOOP DOGG | Doggystyle/Geffen/Interscope |
| 76 | 7 THINGS | MILEY CYRUS | Hollywood |
| 77 | T-SHIRT | SHONTELLE | SRC/Universal Motown |
| 78 | OUR SONG | TAYLOR SWIFT | Big Machine/Universal Republic |
| 79 | WHATEVER IT TAKES | LIFEHOUSE | Geffen |
| 80 | INDEPENDENT | WEBBIE, LIL' PHAT & LIL' BOOSIE | Trill/Asylum/Atlantic |
| 81 | MISERY BUSINESS | PARAMORE | Fueled by Ramen/Atlantic/Lava |
| 82 | WHEN YOU LOOK ME IN THE EYES | JONAS BROTHERS | Hollywood |
| 83 | LIKE YOU'LL NEVER SEE ME AGAIN | ALICIA KEYS | J/RMG |
| 84 | GOT MONEY | LIL WAYNE FEATURING T-PAIN | Cash Money/Universal Motown |
| 85 | LOLLI LOLLI(POP THAT BODY) | THREE 6 MAFIA FEATURING PROJECT PAT, YOUNG D & SUPERPOWER | Hypotize Minds/Columbia |
| 86 | LOVE REMAINS THE SAME | GAVIN ROSSDALE | Interscope |
| 87 | INTO THE NIGHT | SANTANA FEATURING CHAD KROEGER | Arista |
| 88 | FEELS LIKE TONIGHT | DAUGHTRY | RCA/RMG |
| 89 | BYE BYE | MARIAH CAREY | Island/IDJMG |
| 90 | WHAT ABOUT NOW | DAUGHTRY | RCA/RMG |
| 91 | SUMMERTIME | NEW KIDS ON THE BLOCK | Interscope |
| 92 | SAY | JOHN MAYER | Poe Boy/Atlantic |
| 93 | SINGLE LADIES(PUT A RING ON IT) | BEYONCE | Columbia |
| 94 | HYPNOTIZED | PLIES FEATURING AKON | Big Gates/Slip-n-Slide/Atlantic |
| 95 | A MILLI | LIL WAYNE | Cash Money/Universal Motown |
| 96 | STRONGER | KANYE WEST | Roc-A-Fella/Def Jam/IDJMG |
| 97 | THE TIME OF MY LIFE | DAVID COOK | Fremantle/19/RCA/RMG |
| 98 | THAT'S WHAT YOU GET | PARAMORE | Fueled By Ramen/RRP |
| 99 | HERO/HEROINE | BOYS LIKE GIRLS | Columbia |
| 100 | MRS. OFFICER | LIL WAYNE FEATURING BOBBY VALENTINO | Cash Money/Universal Motown |
